dihydrofolate reductase

General Information (Source: NCBI Gene,UniProt)

Text mining Term	dihydrofolate reductase
UniProt ID	DYR_ECOLI
Name	Dihydrofolate reductase
Gene Names	folA Synonyms:tmrA
Taxonomy	Escherichia coli K-12

General annotation

Function	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
Subcellular location

Gene Ontology

GO:0006730	one-carbon metabolic process	BP
GO:0046677	response to antibiotic	BP
GO:0004146	dihydrofolate reductase activity	MF
GO:0042493	response to drug	BP
GO:0009257	10-formyltetrahydrofolate biosynthetic process	BP
GO:0006545	glycine biosynthetic process	BP
GO:0050661	NADP binding	MF
GO:0009165	nucleotide biosynthetic process	BP
GO:0031427	response to methotrexate	BP

Sequence

>gi|16128042|ref|NP_414590.1| dihydrofolate reductase [Escherichia coli str. K-12 substr. MG1655]
MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDD
RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEF
HDADAQNSHSYCFEILERR

Database Cross Reference

Ensembl Gene
UniGene
PDB	1DRA 1RB3 2ANO 1RX8 1RX3 1RA2 1RE7 1RX6 1RX9 1JOM 1RA1 1RF7 1RX1 1RG7 1RA9 1DHI 1RC4 3OCH 1RX5 2ANQ 3DAU 3DRC 1RX2 1RH3 1RA3 2D0K 1DRE 1TDR 1DYH 4DFR 1DYI 1DDR 2DRC 2INQ 7DFR 1RB2 3KFY 3K74 6DFR 1DRH 1DYJ 3QL3 1DHJ 5DFR 1RA8 1RX4 1RX7 1JOL 1DRB 1RD7 1DDS
RefSeq	NP_414590.1
Pfam	PF00186

PTID

dihydrofolate reductase

General Information (Source: NCBI Gene,UniProt)

General annotation

Gene Ontology

Sequence

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Database Cross Reference