dihydrofolate reductase

General Information (Source: NCBI Gene,UniProt)

Text mining Term	dihydrofolate reductase
UniProt ID	DYR_ECOLI
Name	Dihydrofolate reductase
Gene Names	folA Synonyms:tmrA
Taxonomy	Escherichia coli K-12

General annotation

Function	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
Subcellular location

Gene Ontology

GO:0050661	NADP binding	MF
GO:0009165	nucleotide biosynthetic process	BP
GO:0006545	glycine biosynthetic process	BP
GO:0006730	one-carbon metabolic process	BP
GO:0009257	10-formyltetrahydrofolate biosynthetic process	BP
GO:0031427	response to methotrexate	BP
GO:0042493	response to drug	BP
GO:0046677	response to antibiotic	BP
GO:0004146	dihydrofolate reductase activity	MF

Sequence

>gi|16128042|ref|NP_414590.1| dihydrofolate reductase [Escherichia coli str. K-12 substr. MG1655]
MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDD
RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEF
HDADAQNSHSYCFEILERR

Database Cross Reference

Ensembl Gene
UniGene
PDB	1RX3 1DHI 2DRC 1DDS 2ANO 1RX6 1DRA 1RD7 3KFY 1DYH 1DYI 1RB3 1RA2 1RX8 1TDR 6DFR 1RB2 1RX2 3K74 1DRB 1RF7 1JOM 1DHJ 4DFR 7DFR 1RH3 2ANQ 1JOL 1RX5 1RE7 3QL3 1RA3 2D0K 1RC4 3DRC 2INQ 1RX7 1DRE 1RA9 1RA1 1RG7 1DDR 1RA8 1DRH 3DAU 1RX1 1RX4 5DFR 1DYJ 3OCH 1RX9
RefSeq	NP_414590.1
Pfam	PF00186

PTID

dihydrofolate reductase

General Information (Source: NCBI Gene,UniProt)

General annotation

Gene Ontology

Sequence

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Database Cross Reference