| Text mining Term | dihydrofolate reductase |
|---|---|
| UniProt ID | DYR_ECOLI |
| Name |
Dihydrofolate reductase |
| Gene Names |
folA
Synonyms:tmrA |
| Taxonomy | Escherichia coli K-12 |
| Function |
Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. |
|---|---|
| Subcellular location |
| GO:0006545 | glycine biosynthetic process | BP |
| GO:0006730 | one-carbon metabolic process | BP |
| GO:0050661 | NADP binding | MF |
| GO:0009257 | 10-formyltetrahydrofolate biosynthetic process | BP |
| GO:0046677 | response to antibiotic | BP |
| GO:0009165 | nucleotide biosynthetic process | BP |
| GO:0004146 | dihydrofolate reductase activity | MF |
| GO:0042493 | response to drug | BP |
| GO:0031427 | response to methotrexate | BP |
>gi|16128042|ref|NP_414590.1| dihydrofolate reductase [Escherichia coli str. K-12 substr. MG1655] MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDD RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEF HDADAQNSHSYCFEILERR |
| Ensembl Gene | |
|---|---|
| UniGene | |
| PDB |
1RB3 3QL3 1DHJ 1DYH 6DFR 1RX1 1DRH 4DFR 1JOL 1RE7 1RD7 7DFR 1DYJ 3DRC 1RA3 2D0K 1DYI 1DDS 2INQ 1TDR 2ANO 1RX8 1RX3 1RX9 1DHI 1RX6 1JOM 1RB2 1RA1 3KFY 3OCH 1RH3 1RX2 1DDR 3K74 2ANQ 1RA8 1RA9 1RC4 1RG7 1DRA 1RX4 1DRB 1DRE 1RX7 3DAU 5DFR 1RF7 1RX5 1RA2 2DRC |
| RefSeq |
NP_414590.1 |
| Pfam |
PF00186 |