dihydrofolate reductase

General Information (Source: NCBI Gene,UniProt)

Text mining Term	dihydrofolate reductase
UniProt ID	DYR_ECOLI
Name	Dihydrofolate reductase
Gene Names	folA Synonyms:tmrA
Taxonomy	Escherichia coli K-12

General annotation

Function	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
Subcellular location

Gene Ontology

GO:0046677	response to antibiotic	BP
GO:0031427	response to methotrexate	BP
GO:0042493	response to drug	BP
GO:0050661	NADP binding	MF
GO:0009257	10-formyltetrahydrofolate biosynthetic process	BP
GO:0006730	one-carbon metabolic process	BP
GO:0009165	nucleotide biosynthetic process	BP
GO:0006545	glycine biosynthetic process	BP
GO:0004146	dihydrofolate reductase activity	MF

Sequence

>gi|16128042|ref|NP_414590.1| dihydrofolate reductase [Escherichia coli str. K-12 substr. MG1655]
MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDD
RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEF
HDADAQNSHSYCFEILERR

Database Cross Reference

Ensembl Gene
UniGene
PDB	7DFR 1RX5 1DYH 1RH3 1RX8 1DHI 1DYJ 1DDS 1RX9 1RA2 1RA8 1DRE 3K74 1RB3 1DRH 2DRC 1RX7 1DRB 4DFR 5DFR 1DYI 2ANQ 1DHJ 1RX3 2D0K 3KFY 1RA1 1RF7 3OCH 1JOM 3DAU 2ANO 1RX4 1RX2 1RA3 1DRA 1RB2 1RA9 1JOL 1RE7 1DDR 6DFR 3QL3 1RC4 1RX1 1TDR 1RD7 3DRC 1RG7 2INQ 1RX6
RefSeq	NP_414590.1
Pfam	PF00186

PTID

dihydrofolate reductase

General Information (Source: NCBI Gene,UniProt)

General annotation

Gene Ontology

Sequence

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Database Cross Reference