| Text mining Term | dihydrofolate reductase |
|---|---|
| UniProt ID | DYR_ECOLI |
| Name |
Dihydrofolate reductase |
| Gene Names |
folA
Synonyms:tmrA |
| Taxonomy | Escherichia coli K-12 |
| Function |
Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. |
|---|---|
| Subcellular location |
| GO:0009165 | nucleotide biosynthetic process | BP |
| GO:0050661 | NADP binding | MF |
| GO:0004146 | dihydrofolate reductase activity | MF |
| GO:0042493 | response to drug | BP |
| GO:0006730 | one-carbon metabolic process | BP |
| GO:0031427 | response to methotrexate | BP |
| GO:0046677 | response to antibiotic | BP |
| GO:0009257 | 10-formyltetrahydrofolate biosynthetic process | BP |
| GO:0006545 | glycine biosynthetic process | BP |
>gi|16128042|ref|NP_414590.1| dihydrofolate reductase [Escherichia coli str. K-12 substr. MG1655] MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDD RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEF HDADAQNSHSYCFEILERR |
| Ensembl Gene | |
|---|---|
| UniGene | |
| PDB |
1RA9 1RX2 2ANO 1RX5 3K74 1RF7 1RX1 1DDR 1RB2 1DDS 3KFY 3OCH 7DFR 1DRE 1TDR 2ANQ 3QL3 1JOM 2D0K 1DRB 1RX3 1RB3 1RE7 1RC4 5DFR 4DFR 1DHJ 3DRC 1DYI 3DAU 1RA8 1DHI 1RG7 1RA2 1JOL 1DYJ 1RA3 1DRA 1RX7 1DRH 1RA1 2DRC 1RX4 1DYH 1RD7 1RX6 1RX8 2INQ 6DFR 1RX9 1RH3 |
| RefSeq |
NP_414590.1 |
| Pfam |
PF00186 |