dihydrofolate reductase

General Information (Source: NCBI Gene,UniProt)

Text mining Term	dihydrofolate reductase
UniProt ID	DYR_ECOLI
Name	Dihydrofolate reductase
Gene Names	folA Synonyms:tmrA
Taxonomy	Escherichia coli K-12

General annotation

Function	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
Subcellular location

Gene Ontology

GO:0006545	glycine biosynthetic process	BP
GO:0042493	response to drug	BP
GO:0031427	response to methotrexate	BP
GO:0050661	NADP binding	MF
GO:0009257	10-formyltetrahydrofolate biosynthetic process	BP
GO:0009165	nucleotide biosynthetic process	BP
GO:0004146	dihydrofolate reductase activity	MF
GO:0046677	response to antibiotic	BP
GO:0006730	one-carbon metabolic process	BP

Sequence

>gi|16128042|ref|NP_414590.1| dihydrofolate reductase [Escherichia coli str. K-12 substr. MG1655]
MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDD
RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEF
HDADAQNSHSYCFEILERR

Database Cross Reference

Ensembl Gene
UniGene
PDB	6DFR 2DRC 3KFY 4DFR 1DYH 1RX9 1RE7 1RA2 1RH3 1DDS 1RX6 3K74 1RX5 1DHI 1RX2 1RX1 1DHJ 1DYI 1DDR 1RG7 1RC4 1RB3 2D0K 3DRC 1DRB 1DRA 1JOL 3DAU 1RA9 1RX7 2INQ 1RX4 2ANO 2ANQ 1RB2 1RX8 1TDR 5DFR 7DFR 1RF7 1DRH 1RA8 1RX3 1DYJ 1RA3 1DRE 1RA1 1RD7 3OCH 1JOM 3QL3
RefSeq	NP_414590.1
Pfam	PF00186

PTID

dihydrofolate reductase

General Information (Source: NCBI Gene,UniProt)

General annotation

Gene Ontology

Sequence

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Database Cross Reference