| Text mining Term | dihydrofolate reductase |
|---|---|
| UniProt ID | DYR_ECOLI |
| Name |
Dihydrofolate reductase |
| Gene Names |
folA
Synonyms:tmrA |
| Taxonomy | Escherichia coli K-12 |
| Function |
Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. |
|---|---|
| Subcellular location |
| GO:0031427 | response to methotrexate | BP |
| GO:0042493 | response to drug | BP |
| GO:0050661 | NADP binding | MF |
| GO:0009257 | 10-formyltetrahydrofolate biosynthetic process | BP |
| GO:0046677 | response to antibiotic | BP |
| GO:0004146 | dihydrofolate reductase activity | MF |
| GO:0006545 | glycine biosynthetic process | BP |
| GO:0006730 | one-carbon metabolic process | BP |
| GO:0009165 | nucleotide biosynthetic process | BP |
>gi|16128042|ref|NP_414590.1| dihydrofolate reductase [Escherichia coli str. K-12 substr. MG1655] MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDD RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEF HDADAQNSHSYCFEILERR |
| Ensembl Gene | |
|---|---|
| UniGene | |
| PDB |
1JOL 1RA1 2DRC 3OCH 1DYH 1TDR 1DYJ 3QL3 1RB3 1RX2 1RD7 1RA8 1RG7 3DAU 1RX3 1DRE 1DRH 2D0K 7DFR 2INQ 3DRC 1DDS 5DFR 1DHI 1RE7 1RX8 1RX9 1DRA 3K74 2ANO 3KFY 1RF7 1RA3 1RX4 1DYI 1RA9 1RX1 1RH3 1JOM 1RA2 1RC4 1DDR 6DFR 1RX7 2ANQ 1RX5 4DFR 1DRB 1DHJ 1RB2 1RX6 |
| RefSeq |
NP_414590.1 |
| Pfam |
PF00186 |