| Text mining Term | dihydrofolate reductase |
|---|---|
| UniProt ID | DYR_ECOLI |
| Name |
Dihydrofolate reductase |
| Gene Names |
folA
Synonyms:tmrA |
| Taxonomy | Escherichia coli K-12 |
| Function |
Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. |
|---|---|
| Subcellular location |
| GO:0031427 | response to methotrexate | BP |
| GO:0050661 | NADP binding | MF |
| GO:0009257 | 10-formyltetrahydrofolate biosynthetic process | BP |
| GO:0006730 | one-carbon metabolic process | BP |
| GO:0004146 | dihydrofolate reductase activity | MF |
| GO:0046677 | response to antibiotic | BP |
| GO:0042493 | response to drug | BP |
| GO:0006545 | glycine biosynthetic process | BP |
| GO:0009165 | nucleotide biosynthetic process | BP |
>gi|16128042|ref|NP_414590.1| dihydrofolate reductase [Escherichia coli str. K-12 substr. MG1655] MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDD RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEF HDADAQNSHSYCFEILERR |
| Ensembl Gene | |
|---|---|
| UniGene | |
| PDB |
3KFY 1RX4 1RX1 1DDS 1RA9 1RA8 2ANO 1RA2 1RB2 1TDR 1RA3 5DFR 1RX6 1RA1 1RX2 3QL3 1RX7 3K74 3OCH 1JOL 1RX8 1DRE 1DYI 1JOM 7DFR 1DHJ 1DYH 1RF7 1RX3 2D0K 6DFR 1RB3 1DDR 4DFR 3DRC 1RH3 1RG7 1DYJ 1RX9 3DAU 1RD7 2DRC 1RX5 1RE7 2ANQ 1DRB 1DRH 1DHI 1DRA 2INQ 1RC4 |
| RefSeq |
NP_414590.1 |
| Pfam |
PF00186 |