| Text mining Term | dihydrofolate reductase |
|---|---|
| UniProt ID | DYR_ECOLI |
| Name |
Dihydrofolate reductase |
| Gene Names |
folA
Synonyms:tmrA |
| Taxonomy | Escherichia coli K-12 |
| Function |
Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. |
|---|---|
| Subcellular location |
| GO:0009165 | nucleotide biosynthetic process | BP |
| GO:0006545 | glycine biosynthetic process | BP |
| GO:0046677 | response to antibiotic | BP |
| GO:0031427 | response to methotrexate | BP |
| GO:0006730 | one-carbon metabolic process | BP |
| GO:0050661 | NADP binding | MF |
| GO:0042493 | response to drug | BP |
| GO:0004146 | dihydrofolate reductase activity | MF |
| GO:0009257 | 10-formyltetrahydrofolate biosynthetic process | BP |
>gi|16128042|ref|NP_414590.1| dihydrofolate reductase [Escherichia coli str. K-12 substr. MG1655] MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDD RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEF HDADAQNSHSYCFEILERR |
| Ensembl Gene | |
|---|---|
| UniGene | |
| PDB |
1DHJ 1DYI 7DFR 1RG7 1RX7 1RX9 1RE7 1RB2 2ANQ 2ANO 1DYH 3QL3 4DFR 3KFY 1DHI 1RA9 1RX3 1RF7 2DRC 1DDR 1RX2 1RX4 1RA1 1RX8 1DDS 1RA8 1DRA 3DAU 1RH3 1DYJ 1RB3 1RX5 1RX6 1DRB 1JOM 1JOL 1RA2 3OCH 5DFR 3K74 1DRH 1RC4 1RX1 1TDR 1RA3 3DRC 6DFR 1RD7 2D0K 2INQ 1DRE |
| RefSeq |
NP_414590.1 |
| Pfam |
PF00186 |