| Text mining Term | dihydrofolate reductase |
|---|---|
| UniProt ID | DYR_ECOLI |
| Name |
Dihydrofolate reductase |
| Gene Names |
folA
Synonyms:tmrA |
| Taxonomy | Escherichia coli K-12 |
| Function |
Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. |
|---|---|
| Subcellular location |
| GO:0046677 | response to antibiotic | BP |
| GO:0042493 | response to drug | BP |
| GO:0050661 | NADP binding | MF |
| GO:0004146 | dihydrofolate reductase activity | MF |
| GO:0031427 | response to methotrexate | BP |
| GO:0006730 | one-carbon metabolic process | BP |
| GO:0009165 | nucleotide biosynthetic process | BP |
| GO:0006545 | glycine biosynthetic process | BP |
| GO:0009257 | 10-formyltetrahydrofolate biosynthetic process | BP |
>gi|16128042|ref|NP_414590.1| dihydrofolate reductase [Escherichia coli str. K-12 substr. MG1655] MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDD RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEF HDADAQNSHSYCFEILERR |
| Ensembl Gene | |
|---|---|
| UniGene | |
| PDB |
1JOL 2INQ 1DRE 2D0K 1RX7 3KFY 1RB3 1DRA 1DHI 5DFR 1RE7 1RX9 1RX8 7DFR 2ANQ 1RA3 1RA1 1RX5 1TDR 3K74 1DDR 1RX1 1DYJ 1RX6 1RA8 6DFR 4DFR 1DHJ 1JOM 1RC4 1RH3 1DRH 1DYH 3OCH 1DYI 2DRC 1RD7 1RF7 2ANO 1DRB 1RA9 1RA2 3QL3 1RX2 1RB2 1DDS 1RG7 3DRC 1RX3 1RX4 3DAU |
| RefSeq |
NP_414590.1 |
| Pfam |
PF00186 |