| Text mining Term | dihydrofolate reductase |
|---|---|
| UniProt ID | DYR_ECOLI |
| Name |
Dihydrofolate reductase |
| Gene Names |
folA
Synonyms:tmrA |
| Taxonomy | Escherichia coli K-12 |
| Function |
Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. |
|---|---|
| Subcellular location |
| GO:0046677 | response to antibiotic | BP |
| GO:0009165 | nucleotide biosynthetic process | BP |
| GO:0006545 | glycine biosynthetic process | BP |
| GO:0050661 | NADP binding | MF |
| GO:0031427 | response to methotrexate | BP |
| GO:0042493 | response to drug | BP |
| GO:0006730 | one-carbon metabolic process | BP |
| GO:0004146 | dihydrofolate reductase activity | MF |
| GO:0009257 | 10-formyltetrahydrofolate biosynthetic process | BP |
>gi|16128042|ref|NP_414590.1| dihydrofolate reductase [Escherichia coli str. K-12 substr. MG1655] MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDD RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEF HDADAQNSHSYCFEILERR |
| Ensembl Gene | |
|---|---|
| UniGene | |
| PDB |
1RA1 3KFY 3QL3 1RX2 1RX7 1DYH 1RA2 1DRA 1DRE 1RA8 2ANO 1RD7 1DDS 3OCH 1DHI 2DRC 1RF7 4DFR 2INQ 1RX3 1RX5 2ANQ 1RA3 1DYJ 1RX4 1JOM 3K74 1RB3 1RH3 1DRH 1RX1 1DHJ 1RB2 1RX6 3DRC 7DFR 1RC4 1RX8 1RG7 6DFR 2D0K 1RA9 1TDR 3DAU 1DDR 5DFR 1DYI 1JOL 1RX9 1DRB 1RE7 |
| RefSeq |
NP_414590.1 |
| Pfam |
PF00186 |