| Text mining Term | dihydrofolate reductase |
|---|---|
| UniProt ID | DYR_ECOLI |
| Name |
Dihydrofolate reductase |
| Gene Names |
folA
Synonyms:tmrA |
| Taxonomy | Escherichia coli K-12 |
| Function |
Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. |
|---|---|
| Subcellular location |
| GO:0046677 | response to antibiotic | BP |
| GO:0042493 | response to drug | BP |
| GO:0006730 | one-carbon metabolic process | BP |
| GO:0050661 | NADP binding | MF |
| GO:0009257 | 10-formyltetrahydrofolate biosynthetic process | BP |
| GO:0004146 | dihydrofolate reductase activity | MF |
| GO:0031427 | response to methotrexate | BP |
| GO:0006545 | glycine biosynthetic process | BP |
| GO:0009165 | nucleotide biosynthetic process | BP |
>gi|16128042|ref|NP_414590.1| dihydrofolate reductase [Escherichia coli str. K-12 substr. MG1655] MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDD RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEF HDADAQNSHSYCFEILERR |
| Ensembl Gene | |
|---|---|
| UniGene | |
| PDB |
1RX1 2ANO 1RX7 3DRC 1DRE 1RF7 3OCH 1RB2 1RX2 1RA9 2ANQ 1DRB 1RB3 2INQ 1DHI 1DRH 7DFR 1RA1 1DRA 1RG7 1JOL 1RX9 2D0K 4DFR 1RA3 1DDS 3K74 1RX5 1DYI 1RE7 1RC4 2DRC 6DFR 1RD7 1DDR 1JOM 3QL3 1TDR 1RA2 1DYH 1RX8 1RX3 1RX6 1RH3 3DAU 5DFR 1RA8 1RX4 1DHJ 1DYJ 3KFY |
| RefSeq |
NP_414590.1 |
| Pfam |
PF00186 |