| Text mining Term | progesterone receptor |
|---|---|
| UniProt ID | PRGR_RAT |
| Name |
Nuclear receptor subfamily 3 group C member 3 PR Progesterone receptor |
| Gene Names |
Pgr
Synonyms:Nr3c3 |
| Taxonomy | Rattus norvegicus |
| Function |
The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform is involved in activation of c-SRC/MAPK signaling on hormone stimulation (By similarity). |
|---|---|
| Subcellular location |
Nucleus. Cytoplasm. Note=Nucleoplasmic shuttling is both homone- and cell cycle-dependent. On hormone stimulation, retained in the cytoplasm in the G(1) and G(2)/M phases (By similarity). |
| GO:0001553 | luteinization | BP |
| GO:0003700 | sequence-specific DNA binding transcription factor activity | MF |
| GO:0008270 | zinc ion binding | MF |
| GO:0043565 | sequence-specific DNA binding | MF |
| GO:0042562 | hormone binding | MF |
| GO:0045893 | positive regulation of transcription, DNA-dependent | BP |
| GO:0043005 | neuron projection | CC |
| GO:0016101 | diterpenoid metabolic process | BP |
| GO:0045892 | negative regulation of transcription, DNA-dependent | BP |
| GO:0003707 | steroid hormone receptor activity | MF |
| GO:0071373 | cellular response to luteinizing hormone stimulus | BP |
| GO:0005634 | nucleus | CC |
| GO:0071372 | cellular response to follicle-stimulating hormone stimulus | BP |
| GO:0006351 | transcription, DNA-dependent | BP |
| GO:0005496 | steroid binding | MF |
| GO:0005829 | cytosol | CC |
>gi|12408292|ref|NP_074038.1| progesterone receptor [Rattus norvegicus] MTELQAKDPRTLHTSGAAPSPTHVGSPLLARLDPDPFQGSQHSDASSVVSPIPISLDRLLFSRSCQAQEL PDEKTQNQQSLSDVEGAFSGVEASRRRSRNPRAPEKDSRLLDSVLDTLLAPSGPEQSQTSPPACEAITSW CLFGPELPEDPRSVPATKGLLSPLMSRPESKAGDSSGTGAGQKVLPKAVSPPRQLLLPTSGSAHWPGAGV KPSQQPATVEVEEDGGLETEGSAGPLLKSKPRALEGMCSGGGVTANAPGAAPGGVTLVPKEDSRFSAPRV SLEQDAPVAPGRSPLATTVVDFIHVPILPLNHALLAARTRQLLEGDSYDGGAAAQVPFAPPRGSPSAPSP PVPCGDFPDCTYPPEGDPKEDGFPVYGEFQPPGLKIKEEEEGTEAASRSPRPYLLAGASAATFPDFPLPP RPPRAPPSRPGEAAVAAPSAAVSPVSSSGSALECILYKAEGAPPTQGSFAPLPCKPPAASSCLLPRDSLP AAPTSSAAPAIYPPLGLNGLPQLGYQAAVLKDSLPQVYPPYLNYLRPDSEASQSPQYGFDSLPQKICLIC GDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLCAGRNDCIVDKIRRKNCPACRLRKCCQAGMVLGGRKFK KFNKVRVMRALDGVALPQSVAFPNESQTLGQRITFSPNQEIQLVPPLINLLMSIEPDVVYAGHDNTKPDT SSSLLTSLNQLGERQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAP DLILNEQRMKELSFYSLCLTMWQIPQEFVKLQVTHEEFLCMKVLLLLNTIPLEGLRSQSQFEEMRSSYIR ELIKAIGLRQKGVVPSSQRFYQLTKLLDSLHDLVKQLHLYCLNTFIQSRALAVEFPEMMSEVIAAQLPKI LAGMVKPLLFHKK |
| Ensembl Gene | |
|---|---|
| UniGene |
Rn.10303 |
| PDB | |
| RefSeq |
NP_074038.1 |
| Pfam |
PF00104 PF00105 PF02161 |