estrogen receptor

General Information (Source: NCBI Gene,UniProt)

Text mining Term estrogen receptor
UniProt ID ESR1_RAT
Name ER-alpha
Estradiol receptor
ER
Estrogen receptor
Nuclear receptor subfamily 3 group A member 1
Gene Names Esr1
Taxonomy Rattus norvegicus

General annotation

Function Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Can activate the transcriptional activity of TFF1 (By similarity).
Subcellular location Nucleus (By similarity). Cytoplasm (By similarity).

Gene Ontology

GO:0003700 sequence-specific DNA binding transcription factor activity MF
GO:0030284 estrogen receptor activity MF
GO:0019899 enzyme binding MF
GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway BP
GO:0048471 perinuclear region of cytoplasm CC
GO:0044429 mitochondrial part CC
GO:0043234 protein complex CC
GO:0042562 hormone binding MF
GO:0032403 protein complex binding MF
GO:0006351 transcription, DNA-dependent BP
GO:0031798 type 1 metabotropic glutamate receptor binding MF
GO:0043195 terminal button CC
GO:0045944 positive regulation of transcription from RNA polymerase II promoter BP
GO:0030315 T-tubule CC
GO:0070374 positive regulation of ERK1 and ERK2 cascade BP
GO:0045885 positive regulation of survival gene product expression BP
GO:0043526 neuroprotection BP
GO:0005496 steroid binding MF
GO:0060011 Sertoli cell proliferation BP
GO:0008270 zinc ion binding MF
GO:0043204 perikaryon CC
GO:0005634 nucleus CC
GO:0032355 response to estradiol stimulus BP
GO:0002076 osteoblast development BP
GO:0043565 sequence-specific DNA binding MF

Sequence

>gi|6978815|ref|NP_036821.1| estrogen receptor [Rattus norvegicus]
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKMPMERALGEVYVDNSKPAVFNYPEGAAYEFNAAAAAAA
AGASAPVYGQSSITYGPGSEAAAFGANSLGAFPQLNSVSPSPLMLLHPPPHVSPFLHPHGHQVPYYLENE
PSAYAVRDTGPPAFYRSNSDNRRQNGRERLSSSSEKGNMIMESAKETRYCAVCNDYASGYHYGVWSCEGC
KAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDLE
GRNEMGTSGDMRAANLWPSPLVIKHTKKNSPALSLTADQMVSALLDAEPPLIYSEYDPSRPFSEASMMGL
LTNLADRELVHMINWAKRVPGFGDLNLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQG
KCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKINDT
LIHLMAKAGLTLQQQHRRLAQLLLILSHIRHMSNKGMEHLYNMKCKNVVPLYDLLLEMLDAHRLHAPASR
MGVPPEEPSQSQLTTTSSTSAHSLQTYYIPPEAEGFPNTI

Options for BLAST

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Database Cross Reference

Ensembl Gene
UniGene Rn.10595
PDB
RefSeq NP_036821.1
Pfam PF00105
PF12743
PF02159
PF00104