heme oxygenase 1

General Information (Source: NCBI Gene,UniProt)

Text mining Term heme oxygenase 1
UniProt ID HMOX1_RAT
Name HO-1
Heme oxygenase 1
HSP32
Gene Names Hmox1
Taxonomy Rattus norvegicus

General annotation

Function Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed.
Subcellular location Microsome. Endoplasmic reticulum.

Gene Ontology

GO:0043524 negative regulation of neuron apoptosis BP
GO:0008219 cell death BP
GO:0042167 heme catabolic process BP
GO:0006644 phospholipid metabolic process BP
GO:0001666 response to hypoxia BP
GO:0004630 phospholipase D activity MF
GO:0045768 positive regulation of anti-apoptosis BP
GO:0020037 heme binding MF
GO:0008217 regulation of blood pressure BP
GO:0006788 heme oxidation BP
GO:0005901 caveola CC
GO:0008630 DNA damage response, signal transduction resulting in induction of apoptosis BP
GO:0043627 response to estrogen stimulus BP
GO:0045766 positive regulation of angiogenesis BP
GO:0043305 negative regulation of mast cell degranulation BP
GO:0043392 negative regulation of DNA binding BP
GO:0005792 microsome CC
GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity BP
GO:0007264 small GTPase mediated signal transduction BP
GO:0042542 response to hydrogen peroxide BP
GO:0031670 cellular response to nutrient BP
GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress BP
GO:0048662 negative regulation of smooth muscle cell proliferation BP
GO:0001525 angiogenesis BP
GO:0019899 enzyme binding MF
GO:0004392 heme oxygenase (decyclizing) activity MF
GO:0005783 endoplasmic reticulum CC
GO:0005730 nucleolus CC
GO:0032764 negative regulation of mast cell cytokine production BP
GO:0005829 cytosol CC

Sequence

>gi|6981032|ref|NP_036712.1| heme oxygenase 1 [Rattus norvegicus]
MERPQLDSMSQDLSEALKEATKEVHIRAENSEFMRNFQKGQVSREGFKLVMASLYHIYTALEEEIERNKQ
NPVYAPLYFPEELHRRAALEQDMAFWYGPHWQEAIPYTPATQHYVKRLHEVGGTHPELLVAHAYTRYLGD
LSGGQVLKKIAQKAMALPSSGEGLAFFTFPSIDNPTKFKQLYRARMNTLEMTPEVKHRVTEEAKTAFLLN
IELFEELQALLTEEHKDQSPSQTEFLRQRPASLVQDTTSAETPRGKSQISTSSSQTPLLRWVLTLSFLLA
TVAVGIYAM

Options for BLAST

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Database Cross Reference

Ensembl Gene ENSRNOT00000019192
UniGene Rn.3160
PDB 1ULX
2ZVU
1UBB
2E7E
1IX4
1J2C
1DVE
1VGI
1IVJ
1IRM
1DVG
3I9U
3I9T
1J02
1IX3
2DY5
RefSeq NP_036712.1
Pfam PF01126