| Text mining Term | gephyrin |
|---|---|
| UniProt ID | GEPH_RAT |
| Name |
Domain G Molybdopterin molybdenumtransferase Molybdopterin adenylyltransferase Putative glycine receptor-tubulin linker protein MPT Mo-transferase MPT adenylyltransferase Domain E Gephyrin |
| Gene Names |
Gphn
Synonyms:Gph |
| Taxonomy | Rattus norvegicus |
| Function |
Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (By similarity). Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released. |
|---|---|
| Subcellular location |
Cell junction, synapse. Cell junction, synapse, postsynaptic cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Note=Cytoplasmic face of glycinergic postsynaptic membranes. |
| GO:0005886 | plasma membrane | CC |
| GO:0030674 | protein binding, bridging | MF |
| GO:0045211 | postsynaptic membrane | CC |
| GO:0006777 | Mo-molybdopterin cofactor biosynthetic process | BP |
| GO:0060077 | inhibitory synapse | CC |
| GO:0032947 | protein complex scaffold | MF |
| GO:0005737 | cytoplasm | CC |
| GO:0030054 | cell junction | CC |
| GO:0015631 | tubulin binding | MF |
| GO:0046872 | metal ion binding | MF |
| GO:0007416 | synapse assembly | BP |
| GO:0006605 | protein targeting | BP |
| GO:0016740 | transferase activity | MF |
| GO:0005102 | receptor binding | MF |
| GO:0051260 | protein homooligomerization | BP |
| GO:0005524 | ATP binding | MF |
| GO:0042803 | protein homodimerization activity | MF |
| GO:0005856 | cytoskeleton | CC |
>gi|88853561|ref|NP_074056.2| gephyrin [Rattus norvegicus] MATEGMILTNHDHQIRVGVLTVSDSCFRNLAEDRSGINLKDLVQDPSLLGGTISAYKIVPDEIEEIKETL IDWCDEKELNLILTTGGTGFAPRDVTPEATKEVIEREAPGMALAMLMGSLNVTPLGMLSRPVCGIRGKTL IINLPGSKKGSQECFQFILPALPHAIDLLRDAIVKVKEVHDELEDLPSPPPPLSPPPTTSPHKQTEDKGV QCEEEEEEKKDSGVASTEDSSSSHITAAALAAKIPDSIISRGVQVLPRDTASLSTTPSESPRAQATSRLS TASCPTPKVQSRCSSKENILRASHSAVDITKVARRHRMSPFPLTSMDKAFITVLEMTPVLGTEIINYRDG MGRVLAQDVYAKDNLPPFPASVKDGYAVRAADGPGDRFIIGESQAGEQPTQTVMPGQVMRVTTGAPIPCG ADAVVQVEDTELIRESDDGTEELEVRILVQARPGQDIRPIGHDIKRGECVLAKGTHMGPSEIGLLATVGV TEVEVNKFPVVAVMSTGNELLNPEDDLLPGKIRDSNRSTLLATIQEHGYPTINLGIVGDNPDDLLNALNE GISRADVIITSGGVSMGEKDYLKQVLDIDLHAQIHFGRVFMKPGLPTTFATLDIDGVRKIIFALPGNPVS AVVTCNLFVVPALRKMQGILDPRPTIIKARLSCDVKLDPRPEYHRCILTWHHQEPLPWAQSTGNQMSSRL MSMRSANGLLMLPPKTEQYVELHKGEVVDVMVIGRL |
| Ensembl Gene | |
|---|---|
| UniGene |
Rn.11032 |
| PDB |
1IHC 2FU3 2FTS 1T3E |
| RefSeq |
NP_074056.2 |
| Pfam |
PF03453 PF03454 PF00994 |