| Text mining Term | gephyrin |
|---|---|
| UniProt ID | GEPH_RAT |
| Name |
Domain G MPT adenylyltransferase Putative glycine receptor-tubulin linker protein Gephyrin Molybdopterin molybdenumtransferase Domain E Molybdopterin adenylyltransferase MPT Mo-transferase |
| Gene Names |
Gphn
Synonyms:Gph |
| Taxonomy | Rattus norvegicus |
| Function |
Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (By similarity). Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released. |
|---|---|
| Subcellular location |
Cell junction, synapse. Cell junction, synapse, postsynaptic cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Note=Cytoplasmic face of glycinergic postsynaptic membranes. |
| GO:0045211 | postsynaptic membrane | CC |
| GO:0005886 | plasma membrane | CC |
| GO:0046872 | metal ion binding | MF |
| GO:0060077 | inhibitory synapse | CC |
| GO:0005102 | receptor binding | MF |
| GO:0006777 | Mo-molybdopterin cofactor biosynthetic process | BP |
| GO:0051260 | protein homooligomerization | BP |
| GO:0030674 | protein binding, bridging | MF |
| GO:0005524 | ATP binding | MF |
| GO:0016740 | transferase activity | MF |
| GO:0032947 | protein complex scaffold | MF |
| GO:0005737 | cytoplasm | CC |
| GO:0007416 | synapse assembly | BP |
| GO:0030054 | cell junction | CC |
| GO:0015631 | tubulin binding | MF |
| GO:0006605 | protein targeting | BP |
| GO:0042803 | protein homodimerization activity | MF |
| GO:0005856 | cytoskeleton | CC |
>gi|88853561|ref|NP_074056.2| gephyrin [Rattus norvegicus] MATEGMILTNHDHQIRVGVLTVSDSCFRNLAEDRSGINLKDLVQDPSLLGGTISAYKIVPDEIEEIKETL IDWCDEKELNLILTTGGTGFAPRDVTPEATKEVIEREAPGMALAMLMGSLNVTPLGMLSRPVCGIRGKTL IINLPGSKKGSQECFQFILPALPHAIDLLRDAIVKVKEVHDELEDLPSPPPPLSPPPTTSPHKQTEDKGV QCEEEEEEKKDSGVASTEDSSSSHITAAALAAKIPDSIISRGVQVLPRDTASLSTTPSESPRAQATSRLS TASCPTPKVQSRCSSKENILRASHSAVDITKVARRHRMSPFPLTSMDKAFITVLEMTPVLGTEIINYRDG MGRVLAQDVYAKDNLPPFPASVKDGYAVRAADGPGDRFIIGESQAGEQPTQTVMPGQVMRVTTGAPIPCG ADAVVQVEDTELIRESDDGTEELEVRILVQARPGQDIRPIGHDIKRGECVLAKGTHMGPSEIGLLATVGV TEVEVNKFPVVAVMSTGNELLNPEDDLLPGKIRDSNRSTLLATIQEHGYPTINLGIVGDNPDDLLNALNE GISRADVIITSGGVSMGEKDYLKQVLDIDLHAQIHFGRVFMKPGLPTTFATLDIDGVRKIIFALPGNPVS AVVTCNLFVVPALRKMQGILDPRPTIIKARLSCDVKLDPRPEYHRCILTWHHQEPLPWAQSTGNQMSSRL MSMRSANGLLMLPPKTEQYVELHKGEVVDVMVIGRL |
| Ensembl Gene | |
|---|---|
| UniGene |
Rn.11032 |
| PDB |
1IHC 1T3E 2FTS 2FU3 |
| RefSeq |
NP_074056.2 |
| Pfam |
PF03453 PF00994 PF03454 |