cystathionine gamma lyase

General Information (Source: NCBI Gene,UniProt)

Text mining Term	cystathionine gamma lyase
UniProt ID	CGL_RAT
Name	PRB-RA Probasin-related antigen Gamma-cystathionase Cystathionine gamma-lyase
Gene Names	Cth
Taxonomy	Rattus norvegicus

General annotation

Function	Catalyzes the last step in the transsulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure (By similarity).
Subcellular location	Cytoplasm.

Function

Catalyzes the last step in the transsulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure (By similarity).

Subcellular location

Cytoplasm.

Gene Ontology

GO:0030308	negative regulation of cell growth	BP
GO:0080146	L-cysteine desulfhydrase activity	MF
GO:0004121	cystathionine beta-lyase activity	MF
GO:0018272	protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine	BP
GO:0008285	negative regulation of cell proliferation	BP
GO:0019346	transsulfuration	BP
GO:0006749	glutathione metabolic process	BP
GO:0019344	cysteine biosynthetic process	BP
GO:0030170	pyridoxal phosphate binding	MF
GO:0004123	cystathionine gamma-lyase activity	MF
GO:0070814	hydrogen sulfide biosynthetic process	BP
GO:0005737	cytoplasm	CC

Sequence

>gi|8393215|ref|NP_058770.1| cystathionine gamma-lyase [Rattus norvegicus]
MQKDASSSGFLPSFQHFATQAIHVGPEPEQWSSRAVVLPISLATTFKQDSPGQSSGFVYSRSGNPTRNCL
EKAVAALDGAKHCLTFARGLAATTTITHLLKAGDEVICMDEVYGGTNRYFRRVASEFGLKISFVDCSKTK
LLEAAITPQTKLVWIETPTNPTLKLADIKACAQIVHKHKDIILVVDNTFMSAYFQRPLALGADICMCSAT
KYMNGHSDVVMGLVSVTSDDLNERLRFLQNSLGAVPSPFDCYLCCRGLKTLQIRMEKHFRNGMAVARFLE
SNPRVEKVIYPGLPSHPQHELAKRQCTGCPGMVSFYIKGTLQHAQVFLKNIKLFALAESLGGYESLAELP
AIMTHASVPEKDRATLGISDTLIRLSVGLEDEKDLLEDLGQALKAAHP

Database Cross Reference

Ensembl Gene
UniGene	Rn.3881
PDB
RefSeq	NP_058770.1
Pfam	PF01053

PTID

cystathionine gamma lyase

General Information (Source: NCBI Gene,UniProt)

General annotation

Gene Ontology

Sequence

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Database Cross Reference