heat shock protein 60

General Information (Source: NCBI Gene,UniProt)

Text mining Term heat shock protein 60
UniProt ID CH60_MOUSE
Name 60 kDa chaperonin
CPN60
60 kDa heat shock protein, mitochondrial
Hsp60
Mitochondrial matrix protein P1
HSP-60
Chaperonin 60
HSP-65
Heat shock protein 60
Gene Names Hspd1
Synonyms:Hsp60
Taxonomy Mus musculus

General annotation

Function Implicated in mitochondrial protein import and macromolecular assembly. May facilitate the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix.
Subcellular location Mitochondrion matrix (By similarity).

Gene Ontology

GO:0042110 T cell activation BP
GO:0044459 plasma membrane part CC
GO:0032729 positive regulation of interferon-gamma production BP
GO:0001530 lipopolysaccharide binding MF
GO:0005743 mitochondrial inner membrane CC
GO:0032727 positive regulation of interferon-alpha production BP
GO:0005524 ATP binding MF
GO:0050870 positive regulation of T cell activation BP
GO:0030141 secretory granule CC
GO:0005759 mitochondrial matrix CC

Sequence

>gi|183396771|ref|NP_034607.3| 60 kDa heat shock protein, mitochondrial [Mus musculus]
MLRLPTVLRQMRPVSRALAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGS
PKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEI
RRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKDIGNIISDAMKKVGRKGVITVKDGKTLNDE
LEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSVQSIVPALEIANAHRKPLVIIAEDVDG
EALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLNLNLEDVQAHDLGKVGEVIV
TKDDAMLLKGKGDKAHIEKRIQEITEQLDITTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDR
VTDALNATRAAVEEGIVLGGGCALLRCIPALDSLKPANEDQKIGIEIIKRALKIPAMTIAKNAGVEGSLI
VEKILQSSSEVGYDAMLGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEAVVTEIPKEEKDPGMGA
MGGMGGGMGGGMF

Options for BLAST

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Database Cross Reference

Ensembl Gene ENSMUST00000027123
UniGene Mm.1777
PDB
RefSeq NP_034607.3
Pfam PF00118