caspase 2

General Information (Source: NCBI Gene,UniProt)

Text mining Term caspase 2
UniProt ID CASP2_MOUSE
Name Neural precursor cell expressed developmentally down-regulated protein 2
CASP-2
Caspase-2
NEDD-2
Caspase-2 subunit p13
Protease ICH-1
Caspase-2 subunit p12
Caspase-2 subunit p18
Gene Names Casp2
Taxonomy Mus musculus

General annotation

Function Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival. May be important in multistep carcinogenesis.
Subcellular location

Gene Ontology

GO:0006915 apoptotic process BP
GO:0006917 induction of apoptosis BP
GO:0005634 nucleus CC

Sequence

>gi|6680848|ref|NP_031636.1| caspase-2 [Mus musculus]
MAAPSGRSQSSLHRKGLMAADRRSRILAVCGMHPDHQETLKKNRVVLAKQLLLSELLEHLLEKDIITLEM
RELIQAKGGSFSQNVELLNLLPKRGPQAFDAFCEALRETRQGHLEDLLLTTLSDIQHVLPPLSCDYDTSL
PFSVCESCPPHKQLRLSTDATEHSLDNGDGPPCLLVKPCTPEFYQAHYQLAYRLQSQPRGLALVLSNVHF
TGEKDLEFRSGGDVDHTTLVTLFKLLGYNVHVLHDQTAQEMQEKLQNFAQLPAHRVTDSCVVALLSHGVE
GGIYGVDGKLLQLQEVFRLFDNANCPSLQNKPKMFFIQACRGDETDRGVDQQDGKNHTQSPGCEESDAGK
EELMKMRLPTRSDMICGYACLKGNAAMRNTKRGSWYIEALTQVFSERACDMHVADMLVKVNALIKEREGY
APGTEFHRCKEMSEYCSTLCQQLYLFPGYPPT

Options for BLAST

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Database Cross Reference

Ensembl Gene ENSMUST00000031895
UniGene Mm.3921
PDB
RefSeq NP_031636.1
Pfam PF00656
PF00619