| Text mining Term | nNOS |
|---|---|
| UniProt ID | NOS1_RAT |
| Name |
NOS type I nNOS BNOS N-NOS Neuronal NOS Nitric oxide synthase, brain Peptidyl-cysteine S-nitrosylase NOS1 Constitutive NOS NC-NOS |
| Gene Names |
Nos1
Synonyms:Bnos |
| Taxonomy | Rattus norvegicus |
| Function |
Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Inhibitory transmitter for non-adrenergic and non-cholinergic nerves in the colorectum. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR. Inhibitory transmitter for non- adrenergic and non-cholinergic nerves in the colorectum. |
|---|---|
| Subcellular location |
Cell membrane, sarcolemma; Peripheral membrane protein (By similarity). Cell projection, dendritic spine (By similarity). Note=In skeletal muscle, it is localized beneath the sarcolemma of fast-twitch muscle fiber by associating with the dystrophin glycoprotein complex (By similarity). In neurons, enriched in dendritic spines. |
| GO:0010243 | response to organic nitrogen | BP |
| GO:0016597 | amino acid binding | MF |
| GO:0032496 | response to lipopolysaccharide | BP |
| GO:0001666 | response to hypoxia | BP |
| GO:0014823 | response to activity | BP |
| GO:0019899 | enzyme binding | MF |
| GO:0006527 | arginine catabolic process | BP |
| GO:0007565 | female pregnancy | BP |
| GO:0050661 | NADP binding | MF |
| GO:0001917 | photoreceptor inner segment | CC |
| GO:0045471 | response to ethanol | BP |
| GO:0020037 | heme binding | MF |
| GO:0010181 | FMN binding | MF |
| GO:0043434 | response to peptide hormone stimulus | BP |
| GO:0043627 | response to estrogen stimulus | BP |
| GO:0005741 | mitochondrial outer membrane | CC |
| GO:0043197 | dendritic spine | CC |
| GO:0051930 | regulation of sensory perception of pain | BP |
| GO:0012506 | vesicle membrane | CC |
| GO:0035094 | response to nicotine | BP |
| GO:0042582 | azurophil granule | CC |
| GO:0048471 | perinuclear region of cytoplasm | CC |
| GO:0010288 | response to lead ion | BP |
| GO:0050660 | flavin adenine dinucleotide binding | MF |
| GO:0033197 | response to vitamin E | BP |
| GO:0031965 | nuclear membrane | CC |
| GO:0042383 | sarcolemma | CC |
| GO:0045909 | positive regulation of vasodilation | BP |
| GO:0043066 | negative regulation of apoptotic process | BP |
| GO:0045822 | negative regulation of heart contraction | BP |
| GO:0005625 | soluble fraction | CC |
| GO:0009408 | response to heat | BP |
| GO:0046676 | negative regulation of insulin secretion | BP |
| GO:0004517 | nitric-oxide synthase activity | MF |
| GO:0045202 | synapse | CC |
| GO:0005624 | membrane fraction | CC |
| GO:0045776 | negative regulation of blood pressure | BP |
| GO:0042803 | protein homodimerization activity | MF |
| GO:0046870 | cadmium ion binding | MF |
| GO:0007568 | aging | BP |
| GO:0005516 | calmodulin binding | MF |
| GO:0071731 | response to nitric oxide | BP |
| GO:0006809 | nitric oxide biosynthetic process | BP |
| GO:0005829 | cytosol | CC |
>gi|16258811|ref|NP_434686.1| nitric oxide synthase, brain [Rattus norvegicus] MEENTFGVQQIQPNVISVRLFKRKVGGLGFLVKERVSKPPVIISDLIRGGAAEQSGLIQAGDIILAVNDR PLVDLSYDSALEVLRGIASETHVVLILRGPEGFTTHLETTFTGDGTPKTIRVTQPLGPPTKAVDLSHQPS ASKDQSLAVDRVTGLGNGPQHAQGHGQGAGSVSQANGVAIDPTMKSTKANLQDIGEHDELLKEIEPVLSI LNSGSKATNRGGPAKAEMKDTGIQVDRDLDGKSHKAPPLGGDNDRVFNDLWGKDNVPVVLNNPYSEKEQS PTSGKQSPTKNGSPSRCPRFLKVKNWETDVVLTDTLHLKSTLETGCTEHICMGSIMLPSQHTRKPEDVRT KDQLFPLAKEFLDQYYSSIKRFGSKAHMDRLEEVNKEIESTSTYQLKDTELIYGAKHAWRNASRCVGRIQ WSKLQVFDARDCTTAHGMFNYICNHVKYATNKGNLRSAITIFPQRTDGKHDFRVWNSQLIRYAGYKQPDG STLGDPANVQFTEICIQQGWKAPRGRFDVLPLLLQANGNDPELFQIPPELVLEVPIRHPKFDWFKDLGLK WYGLPAVSNMLLEIGGLEFSACPFSGWYMGTEIGVRDYCDNSRYNILEEVAKKMDLDMRKTSSLWKDQAL VEINIAVLYSFQSDKVTIVDHHSATESFIKHMENEYRCRGGCPADWVWIVPPMSGSITPVFHQEMLNYRL TPSFEYQPDPWNTHVWKGTNGTPTKRRAIGFKKLAEAVKFSAKLMGQAMAKRVKATILYATETGKSQAYA KTLCEIFKHAFDAKAMSMEEYDIVHLEHEALVLVVTSTFGNGDPPENGEKFGCALMEMRHPNSVQEERKY PEPLRFFPRKGPSLSHVDSEAHSLVAARDSQHRSYKVRFNSVSSYSDSRKSSGDGPDLRDNFESTGPLAN VRFSVFGLGSRAYPHFCAFGHAVDTLLEELGGERILKMREGDELCGQEEAFRTWAKKVFKAACDVFCVGD DVNIEKANNSLISNDRSWKRNKFRLTYVAEAPDLTQGLSNVHKKRVSAARLLSRQNLQSPKSSRSTIFVR LHTNGNQELQYQPGDHLGVFPGNHEDLVNALIERLEDAPPANHVVKVEMLEERNTALGVISNWKDESRLP PCTIFQAFKYYLDITTPPTPLQLQQFASLATNEKEKQRLLVLSKGLQEYEEWKWGKNPTMVEVLEEFPSI QMPATLLLTQLSLLQPRYYSISSSPDMYPDEVHLTVAIVSYHTRDGEGPVHHGVCSSWLNRIQADDVVPC FVRGAPSFHLPRNPQVPCILVGPGTGIAPFRSFWQQRQFDIQHKGMNPCPMVLVFGCRQSKIDHIYREET LQAKNKGVFRELYTVYSREPDRPKKYVQDVLQEQLAESVYRALKEQGGHIYVCGDVTMAADVLKAIQRIM TQQGKLSEEDAGVFISRLRDDNRYHEDIFGVTLRTYEVTNRLRSESIAFIEESKKDADEVFSS |
| Ensembl Gene | |
|---|---|
| UniGene |
Rn.10573 |
| PDB |
3N5V 1RS6 3JX2 3N5X 1P6J 3N66 3JWS 3N64 3N6F 3NNZ 1QW6 3N6E 3NLK 3N5Y 3N6A 3JT9 3JWT 1VAG 1M00 3Q99 2G6I 1ZVI 1RS7 3N5W 2G6H 3JX1 3N61 1MMW 3JT7 1K2R 1TLL 3NLN 3DQR 3N62 3B3N 3N63 1LZZ 3PNG 2G6N 3JWV 1CMI 3JT8 3NLV 3N2R 3NLJ 1B8Q 3NLW 3JX3 3HSP 3JX5 1K2S 1QAV 3JX6 3NLM 3NLY 2G6K 3JWU 3HSO 3B3M 1K2T 3N6D 3SVQ 1ZZQ 1P6K 3N67 3PNF 3Q9A 1OM4 3NLR 1K2U 1P6I 2G6M 1P6H 3JTA 3N6G 3NLQ 2HX3 1QWC 3N68 3SVP 3B3O 1F20 3JX0 3N5Z 1OM5 3JX4 3NLO 3N6C 3HSN 2G6J 3N60 3NLP 3NNY 3FC5 2HX4 3NM0 1ZZU 1ZZR 3NLX 3JT4 3B3P 3JT6 1LZX 3N69 3PNE 3JT3 3N65 3N6B 1QAU 1MMV 2G6L 1ZVL 3JT5 3NLZ |
| RefSeq |
NP_434686.1 |
| Pfam |
PF00667 PF00595 PF00175 PF02898 PF00258 |