cytokine receptor (protein family or complex)

General Information (Source: NCBI Gene,UniProt)

Text mining Term cytokine receptor (protein family or complex)
UniProt ID DOME_DROME
Name Protein domeless
Cytokine receptor
Gene Names dome
Taxonomy Drosophila melanogaster

General annotation

Function Critical for epithelial morphogenesis during oogenesis; border cell migration. Required in the germarium for the polarization of follicle cells during encapsulation of germline cells. Required for embryonic segmentation and trachea specification. Essential receptor molecule for upd and JAK/STAT signaling during oogenesis.
Subcellular location Apicolateral cell membrane; Single-pass type I membrane protein. Note=Apicolateral membranes in follical cells.

Gene Ontology

GO:0016324 apical plasma membrane CC
GO:0008284 positive regulation of cell proliferation BP
GO:0006955 immune response BP
GO:0016021 integral to membrane CC
GO:0004725 protein tyrosine phosphatase activity MF
GO:0007442 hindgut morphogenesis BP
GO:0007350 blastoderm segmentation BP
GO:0016327 apicolateral plasma membrane CC
GO:0001745 compound eye morphogenesis BP
GO:0004888 transmembrane signaling receptor activity MF
GO:0007616 long-term memory BP
GO:0007298 border follicle cell migration BP
GO:0007425 epithelial cell fate determination, open tracheal system BP
GO:0007259 JAK-STAT cascade BP

Sequence

>gi|17367176|sp|Q9VWE0.1|DOME_DROME RecName: Full=Cytokine receptor; AltName: Full=Protein domeless; Flags: Precursor
MVAQEQLVLLLMLLAGCRGGANAILDPGWVIPSKVEQLIGGDFNLSCTLNEDYFNGKSAEDCPVEKLYFT
GGGRVYRDSKHIRILNNTTILFSDTNAVEQENDYHCMCDEYVINKSKVYVGTRPLLVRDFNCLDYDFQFM
VCNFTQPPNTVITKYNISYNTNNDWRYSNTLDCNFDSAPVVTCNLTDDNYKRFSETFYFRLSISNALGHE
TQPITINHFERLVPARPGQNLTLLNRTESSVCLSWEMPRRSNYNRGLVWQVRVTPQNFEPITRPSWRNHT
LTIKDTLCLTELPFAGYNYTLRVRVRANQNNTLWSEPMIYAFATAPAPPRRPPRVTYGSFYVYSSEKAMR
FYWEPLEEHELNGPDFRYSISEYRINGTAVDPGLIKVESNSAMIDHWSMSAVHHFLIRSSNSQGLSVNAT
PMTIGPISNRDFKVREPRNIRSVYHPTNKSYTLSWDPPSDQRELQNYTVFWCVPKPGLQSECEGSIRFAE
VASGLHHFTTSPDQLLTLHMAVSANYQSHNTGLHWAICSSDKKDDLAKMEPSIDVATSTSLTVSWSERVC
AVILAGYNLTYCQRSAGRPDNCTTVTIDRYTNKHVIQNLVPYTDYSVKMLMYSDSRVSKYSDELVNRTGE
AAPSQPRELQLIRVTSDSVELAWKPPLLANGVVRAYEGTFRSLHDNVTDTFRVSASADELVNNEKPITYR
LGNLTAFTKYEISVRARTVYPSEPSNVILFSTAIGVPSPPQLYVINNPDQSSRLDWEPPRTPAGRIDFYE
ISLRDNNASCLTSTILPGRNLSYVMATPRCTSHNPFQLAVRAINVEQHPQLNGADAAEGAVLLMSTNGKG
CEARTDALGEEERLQFEAYAANMTAYRLYRSDWGIYGFICTPDTHSVKAMYQTIEVTVAILVLGVIFYLV
YKKYRKMSDIGLVLPQGIMETMKKPIDMGGLGLGLGPDSSVSGGIVCTRVDDSPPYTPQDLPHDFSSCGS
ESSKLLLRTASSSGGGGCVDRDGYDDNHETGPISAVGPPTSYLAMRHGLLVQNDRERERERDREQERERE
QQQQQRESEMDREQSCTNGYIKPTQMKSWGGNGPSDNDHTFSVPSTAMTAPMSQPLSQIPLSGYVPVPIP
QSRFNPAPVQPFGSPAVPSAATAAAASTFFPPAHLLNMDNYVQASDLHKLKPLVAAPLSQTGGPAFAGSS
PATSPPLQLPPVHAASPAAATPKMADIGYTTMEQLQLTGLIKPPLAATVGSPTHAAGGAPGGGNQHSRLQ
PQINGYVTPQDLNAMAHNRHVL

Options for BLAST

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Database Cross Reference

Ensembl Gene
UniGene Dm.2836
PDB
RefSeq NP_523412.1
Pfam PF00041